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Literature summary extracted from

  • Gyamera-Acheampong, C.; Sirois, F.; Denis, N.J.; Mishra, P.; Figeys, D.; Basak, A.; Mbikay, M.
    The precursor to the germ cell-specific PCSK4 proteinase is inefficiently activated in transfected somatic cells: evidence of interaction with the BiP chaperone (2011), Mol. Cell. Biochem., 348, 43-52.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.B24 expressed in HEK-293 cells Mus musculus
3.4.21.B24 expressed in HEK-293 cells Rattus norvegicus
3.4.21.B24 expressed in HEK-293 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.B24 plasma membrane
-
 Mus musculus 5886
-
3.4.21.B24 plasma membrane
-
 Rattus norvegicus 5886
-
3.4.21.B24 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B24 additional information Mus musculus proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells ?
-
 ?
3.4.21.B24 additional information Rattus norvegicus proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells ?
-
 ?
3.4.21.B24 additional information Homo sapiens proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B24 Homo sapiens Q6UW60
-
-
3.4.21.B24 Mus musculus
-
-
-
3.4.21.B24 Rattus norvegicus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.B24 glycoprotein
-
 Mus musculus
3.4.21.B24 glycoprotein
-
 Rattus norvegicus
3.4.21.B24 glycoprotein glycosylation sites are at N465 and N629 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B24 germ cell
-
 Mus musculus
-
3.4.21.B24 germ cell
-
 Rattus norvegicus
-
3.4.21.B24 germ cell
-
 Homo sapiens
-
3.4.21.B24 sperm
-
 Mus musculus
-
3.4.21.B24 sperm
-
 Rattus norvegicus
-
3.4.21.B24 sperm
-
 Homo sapiens
-
3.4.21.B24 testis
-
 Mus musculus
-
3.4.21.B24 testis
-
 Rattus norvegicus
-
3.4.21.B24 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B24 additional information proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells Mus musculus ?
-
 ?
3.4.21.B24 additional information proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells Rattus norvegicus ?
-
 ?
3.4.21.B24 additional information proprotein convertase subtilisin/kexin type 4 is associated with glucose-regulated protein78/immunoglobulin heavy-chain binding protein. The prozymogen cannot efficiently self-activate in somatic cells Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.B24 ? x * about 58000, mature enzyme, SDS-PAGE Homo sapiens
3.4.21.B24 ? x * about 62000, mature enzyme, predicted from amino acid sequence Mus musculus
3.4.21.B24 ? x * about 62000, mature enzyme, predicted from amino acid sequence Rattus norvegicus
3.4.21.B24 ? x * about 62000, mature enzyme, predicted from amino acid sequence Homo sapiens
3.4.21.B24 ? x * about 72000, pro-zymogen, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B24 PC4
-
 Mus musculus
3.4.21.B24 PC4
-
 Rattus norvegicus
3.4.21.B24 PC4
-
 Homo sapiens
3.4.21.B24 PCSK4
-
 Mus musculus
3.4.21.B24 PCSK4
-
 Rattus norvegicus
3.4.21.B24 PCSK4
-
 Homo sapiens
3.4.21.B24 proprotein convertase subtilisin/kexin type 4
-
 Mus musculus
3.4.21.B24 proprotein convertase subtilisin/kexin type 4
-
 Rattus norvegicus
3.4.21.B24 proprotein convertase subtilisin/kexin type 4
-
 Homo sapiens